2,3-bis-benzo[1,3]dioxol-5-ylmethyl-succinic acid

**2,3-Bis-benzo[1,3]dioxol-5-ylmethyl-succinic acid** is a synthetic small molecule compound with the molecular formula C20H18O8 and a molecular weight of approximately 386.4 g/mol. It is primarily studied as an experimental inhibitor of metallo-beta-lactamases—specifically IMP-type enzymes found in antibiotic-resistant bacteria such as *Pseudomonas aeruginosa*. These enzymes hydrolyze beta-lactam antibiotics (including carbapenems), rendering them ineffective. This compound acts by binding to the active site of IMP-type metallo-beta-lactamases and inhibiting their enzymatic activity. Structural studies have shown it forms stable complexes with these enzymes and can protect broad-spectrum antibiotics from degradation in vitro. The compound has not been approved for clinical use and remains at the experimental research stage[1][2][4][8].

Other names

2,3-Bis-Benzo(1,3)Dioxol-5-Ylmethyl-Succinic Acid(2S,3S)-2,3-bis(2H-1,3-benzodioxol-5-ylmethyl)butanedioic acid(2S,3S)-2,3-Bis(1,3-benzodioxol-5-ylmethyl)succinic acidButanedioic acid, 2,3-bis(1,3-benzodioxol-5-ylmethyl)-,(2S,3S)